tag:blogger.com,1999:blog-643148105033484158.post6441606882762583139..comments2013-12-23T08:00:06.468-08:00Comments on ALZUK: TedHutchinsonhttp://www.blogger.com/profile/13140097526458431747noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-643148105033484158.post-33262852391671051332013-12-23T08:00:06.468-08:002013-12-23T08:00:06.468-08:00Neuroenhancement with Vitamin B12—Underestimated N...<a href="http://www.mdpi.com/2072-6643/5/12/5031" rel="nofollow">Neuroenhancement with Vitamin B12—Underestimated Neurological Significance</a><br />Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in different epigenomic regulatory mechanisms and especially in brain development.<br /> A Vitamin B12 deficiency expresses itself by a wide variety of neurological manifestations such as paraesthesias, skin numbness, coordination disorders and reduced nerve conduction velocity.<br /> In elderly people, a latent Vitamin B12 deficiency can be associated with a progressive brain atrophy.<br /> Moderately elevated concentrations of homocysteine (>10 µmol/L) have been associated with an increased risk of dementia, notably Alzheimer’s disease, in many cross-sectional and prospective studies.<br /> Raised plasma concentrations of homocysteine is also associated with both regional and whole brain atrophy, not only in Alzheimer’s disease but also in healthy elderly people. <br />Clinician awareness should be raised to accurately diagnose and treat early Vitamin B12 deficiency to prevent irreversible structural brain damage.<br /><br />It's worth remembering that much of our B12 comes from our gut flora.<br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/22940212" rel="nofollow">Bacteria as vitamin suppliers to their host: a gut microbiota perspective.</a>TedHutchinsonhttps://www.blogger.com/profile/13140097526458431747noreply@blogger.com